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Sabtu, 20 September 2014

Liposomal Encapsulation Helps Deliver Medications More Effectively

By Jody Leach


Nutritional supplements and most medications are meant to target specific physical systems or organs. Intravenous drip and injection are the most effective methods of delivery, transferring necessary chemicals directly to the blood. When swallowed, medications usually face degradation in the acids of the upper digestive tract. Liposomal encapsulation creates a protective barrier, ultimately allowing more complete absorption.

Scientists first became aware of the process during the 1960s, and their discovery ultimately led to new and more effective means of administering drugs internally. Today, it is widely used in the treatment of age-related degenerative conditions affecting vision, stubborn fungal infections, and even some kinds of cancer. Although standard methods of delivery still predominate medically, encapsulation has proven to be a viable alternative.

For drugs to survive the upper digestive tract intact, they need to be protected by some kind of barrier that does not cause any additional physical problems. The best solution so far is to create microscopic drug capsules using a material that is already a part of cellular walls throughout the human organism. When activated using one of three primary methods available today, tiny protective liposome bubbles are formed.

These individual capsules can be ingested together in a medium, and are shielded from damage until they can be absorbed into the bloodstream via the small intestine. In many cases this process improves the overall therapeutic goal, with the added benefit of fewer side effects. While a significant improvement, this method of delivery does not accommodate all drugs, and works best with water-soluble medications.

Because it involves fewer undesirable reactions than invasive delivery, there are immediate advantages of using this process. Liposomes are bio-compatible and biodegradable, leaving behind no undesirable toxins. They not only survive the onslaught of digestive acids, but are able to function as small time-release ports within the gut. When potentially toxic drugs must be used to fight cancers, fewer sensitive tissues face unwanted exposure.

While being used successfully today in many hospitals, there are some drawbacks. Production costs are comparatively high, but are subject to a natural decrease as product use expands. Seal leakage has been an issue in some cases, and simple oxidation processes can diminish effectiveness. Certain drugs may experience a diminished half-life, and their long-term viability may be reduced. Even with these known issues, positive benefits exceed negative reports.

The past ten years have witnessed a transition from primarily medical use to include delivery of cosmetic and nutritional substances. There is ample anecdotal evidence touting the additional well-being that may result from delivering common vitamin dosages in this fashion. Many people subscribe to the idea that vitamin C is a natural enemy of upper respiratory infections, and also believe that this type of delivery increases effectiveness.

Widespread information is available today regarding personal home encapsulation of vitamins, minerals, and herbal extracts. Producing high-quality encapsulated products is both costly and involved, and is not proven to effectively combat aging issues. As this effective method of physical drug delivery is improved and becomes more widespread, consumers will benefit most from its introduction to existing beneficial heal regimens.




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